Erratum: Treatment with SI000413, a New Herbal Formula, Ameliorates Murine Collagen-Induced Arthritis [Biol. Pharm. Bull. 31(7): 1337—1342]

Inhibition of microRNA-34a ameliorates murine collagen-induced arthritis

Rheumatoid arthritis (RA) is one of the most frequently occurring autoimmne diseases, with symptoms including synovium hyperplasia, immune disorder, cartilage damage and bone resorption. It has previously been demonstrated that microRNA-34a (miR-34a) may participate in cell apoptosis, immune activation and bone metabolism, therefore the present study investigated the effects of miR-34a on RA. C...

Collagen-Induced Arthritis Inhibition of Fractalkine Ameliorates Murine

Eupatilin Ameliorates Collagen Induced Arthritis

Eupatilin is the main active component of DA-9601, an extract from Artemisia. Recently, eupatilin was reported to have anti-inflammatory properties. We investigated the anti-arthritic effect of eupatilin in a murine arthritis model and human rheumatoid synoviocytes. DA-9601 was injected into collagen-induced arthritis (CIA) mice. Arthritis score was regularly evaluated. Mouse monocytes were dif...

Biol. Pharm. Bull. 29(9) 1783—1789 (2006)

Recent progress in human genomic information has provided dramatic changes ranging from accidental to theoretical developments within the realm of drug discovery. Identification of lead compounds that can act as target proteins is proving to be easier through the use of combinatorial chemistry and high-throughput screening. This allows for more efficiently selecting compounds with clinically ef...

Biol. Pharm. Bull. 28(6) 1083—1086 (2005)

gers in such complex cellular processes as mitogenic signal transduction, gene expression, and regulation of cell proliferation. Excessive production of ROS may, however, cause oxidative stress, loss of cell function, and ultimately apoptosis or necrosis. Fortunately, cells possess antioxidant molecules which can neutralize ROS before they induce damage on vital components. However, oxidative s...